Nepal is transforming addiction prevention through a groundbreaking WHOled approach that unites different sectors to fight substance abuse. Law enforcement, transportation authorities, and community groups are working together to reduce alcohol consumption and promote wellness. The innovative strategy includes extensive breath analyses, legal victories like the alcohol advertising ban, and comprehensive partnerships across health and social domains. By targeting root causes and creating collaborative networks, Nepal is setting a powerful example of holistic public health intervention. Their multisectoral approach shows how integrated efforts can effectively combat addiction and improve community wellbeing.